Goals from Raul Gonzalez and Julio Baptista gave the reigning Spanish champions a 2-0 victory over Real Betis in La Liga.
Ramos recently turned 35 and had a season littered with injuries which led to him being left out of Spain's Euro 2020 squad
France striker Karim Benzema has joined Real Madrid from Olympique Lyon.
'We are upset because we have lost a great professional and a top-class player,' Real Madrid director of football Arrigo Sacchi said.
Dele Alli condemned Champions League holders Real Madrid to a horrendous Wembley debut with two goals as Tottenham Hotspur reached the last 16 with a stunning 3-1 victory.
Yamal made a nervy start, and a baying home crowd thought he had conceded a penalty when he slid in to tackle Vinicius Jr, but the decision to award a spot kick was overturned after a VAR review.
Coach Fabio Capello said they are targeting another three signings following the arrival of Juventus pair Emerson and Fabio Cannavaro.
Real Madrid stayed on course to retain the Spanish title after they recovered from a first-half sending-off to clinch a 1-0 win over relegation-threatened Real Murcia at the Bernabeu on Sunday. With six matches left to play, Real lead the table on 69 points, nine ahead of Barcelona, who were held 2-2 at Recreativo Huelva on Saturday.
Madrid hailed as 'Masters of the Universe' after crushing Juve
Real are on 81 points with four games to go. They are 17 points ahead of nearest rivals Sevilla.
Sevilla earned a 2-0 home victory over leaders Real Madrid in a pulsating Primera Liga match.
Javier Saviola and Wesley Sneijder set up champions Real Madrid for a laboured 3-1 victory over 10-man Almeria in the Primera Liga on Saturday.
The Portuguese forward, who also scored a treble in the quarter-final against Bayern Munich at the Santiago Bernabeu, and five goals across that tie, is revelling in the central striker's role he has adopted this season.
Pierre-Emerick Aubameyang scored twice as a rejuvenated Barcelona gave a football masterclass to inflict a humiliating 4-0 defeat on rivals Real Madrid on Sunday.
The Italy's World Cup-winning captain signed a three-year contract.
Karim Benzema's hat-trick earned Real Madrid a 3-1 win at reigning European champions Chelsea in their Champions League quarter-final first leg on Wednesday. In another quarter-final match, Villarreal stunned six times European Cup winners Bayern Munich 1-0.
Playing without crowd will be peculiar: Suarez
Real Madrid have no intention of making a quick profit on striker Alvaro Morata after the Champions League winners opted to take him back to the Bernabeu from Juventus last month, the Spanish side's manager Zinedine Zidane has said. Real sold Morata to Juventus two seasons ago but included a buy-back clause in his contract, which they exercised in July after the forward scored 27 goals in 93 games in Italy and three for Spain during the European Championship.
Midfielder Mahamadou Diarra scored his first goal for Real Madrid to earn a dour 1-0 win at Real Betis.
The Riazor jinx returned to haunt Real Madrid and the champions fell 2-1 away to Deportivo Coruna in their Spanish Primera Liga opener on Sunday, while Pep Guardiola's Barcelona were stunned 1-0 away to promoted Numancia. The performance of the day came from Atletico Madrid, who qualified for the Champions League group stage during the week, and stormed to the top of the standings with a 4-0 demolition of another newly promoted side Malaga.
The 61-year-old Italian, who also won the league title with Real in the 1996-97 season during his first spell at the club, had two years left to run on his contract.
Diego Costa scored four goals as Real Madrid were embarrassed 7-3 by rivals Atletico Madrid in the final match of their United States tour, in New Jersey, on Friday
Real Madrid's Gareth Bale has the qualities to fill the void left by his fellow forward Cristiano Ronaldo's move to Juventus, the Spanish side's new manager Julen Lopetegui has said.
Real Madrid's France forward Karim Benzema won the 2022 Ballon d'Or award for the best men's player in the world on Monday, while Barcelona's Spain midfielder Alexia Putellas won the women's award for a second time.
The players celebrated with their families and loved ones in the stadium as each player lifted and kissed the trophy that had Real Madrid etched on it.
Racing Santander came from a goal down to beat Real Madrid 2-1 with two controversial second-half penalties.
Real Madrid supporters urged Cristiano Ronaldo to stay at the club during celebrations at the Santiago Bernabeu stadium on Sunday to mark their third consecutive Champions League title after an open-top bus parade through the Spanish capital.
The striker apologised for his late return from international duty with Brazil last week, but played down reports that a late night party might have contributed to his delay.
The 33-year-old Brazilian fullback extended his existing deal for another year until June 2008.
Barcelona secured a composed 2-0 LaLiga victory at Villarreal on Sunday thanks to goals from Raphinha and Lamine Yamal in a match that tilted firmly in the visitors' favour when the hosts were reduced to 10 men just before the break.
Real Sociedad moved above Real Madrid into second place behind leaders Deportivo after a 3-1 win over an in-form Real Mallorca in the Spanish League.
Real Mallorca rallied from a goal down at half-time to beat the European champs 5-1 in the Spanish League.
A 'winning culture' may be one of the most over used terms in modern football but Real Madrid and Carlo Ancelotti proved on Saturday, at Liverpool's expense, that there truly is meaning and value in the concept.
Franck Ribery wants to leave Bayern Munich and join Real Madrid, sports daily L'Equipe quoted the France midfielder as saying on Thursday.
Holders Real Madrid breezed past Chelsea into the semi-finals of the Champions League with Rodrygo's double securing a 2-0 win at Stamford Bridge.
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